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Hotel Museo Spa Casa Santo Domingo
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75 photos
Hotel Museo Spa Casa Santo Domingo Antigua Exterior photo The resort's swimming poolHotel Museo Spa Casa Santo Domingo Antigua Exterior photo Interior of the hotelHotel Museo Spa Casa Santo Domingo Antigua Exterior photo The photo captures a tranquil outdoor scene at dusk or dawn. A unique, modern-looking building with a high, sloping roof and large windows is the focal point, bathed in a warm, inviting interior light. The structure appears to be nestled into a hills

Hotel Museo Spa Casa Santo Domingo, Antigua

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up to 10% cheaper
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Check rooms and rates
From209US$ /night
Check-in
21May2026Select date
Check-out
22May2026Select date
Rooms and Guests2 Guests, 1 Room
Key details

About the Hotel

3A, Calle Oriente N.28, Antigua, Guatemala, 03001
Perfect
9.1
9.2
/10
4.5
4.5
/5
“Casa Santo Domingo is perfectly positioned in the heart of Antigua, allowing easy access to the city's vibrant culture and stunning architecture.”view full review

Hotel Museo Spa Casa Santo Domingo (5-star) offers a unique blend of art, history, and wellness in an exceptional setting. This Antigua hotel features luxurious accommodations, a museum complex, and various dining options, providing an immersive cultural experience.

Rooms & Amenities

The spacious rooms at Hotel Museo Spa Casa Santo Domingo feature scenic views and are equipped with smart TVs, mini-bars, and free Wi-Fi. Among its 134 rooms, 26 are designed with SPAliving, providing direct access to wellness facilities.

Dining Options

Dining options include El Refectorio, offering refined international dishes made with local produce; El Tenedor del Cerro, surrounded by nature; and Bar Cabildo, a cozy space for drinks and socializing. Guests can enjoy weekend buffets featuring typical Guatemalan dishes.

Leisure & Attractions

The hotel's spa offers a range of wellness treatments and facilities, including pools, jacuzzis, and saunas. Guests can explore the hotel's six permanent museums and two art galleries while experiencing the cultural offerings of Antigua, like the Holy Week festivities.

Business & Services

Hotel Museo Spa Casa Santo Domingo has comprehensive business facilities and event spaces for meetings and seminars, supported by a dedicated Meeting Planner. The hotel's services include room service, concierge, and transportation options within proximity to bus stations for convenient access.

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Select your room type

Hotel Museo Spa Casa Santo Domingo offers a variety of rooms including double rooms, family rooms, and suites with breakfast, free cancelations, and special deals
Suite Spa Access ADULTS ONLY
Suite Spa Access ADULTS ONLY
2 persons
510 sq. feet 
2 Double beds
Fireplace
Air conditioning
room details
Executive King Room
Executive King Room
2 persons
510 sq. feet 
1 King-size bed
Fireplace
Air conditioning
room details
Luxury Suite Sauna Spa Bath
Luxury Suite Sauna Spa Bath
2 persons
1080 sq. feet 
1 King-size bed
Sauna
Fireplace
room details
Deluxe Suite
Deluxe Suite
2 persons
1080 sq. feet 
1 King-size bed
Fireplace
Air conditioning
room details
Click button to see more rooms
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Show all roomsLess

Price and Room Availability Calendar

Check availability and prices for your dates now!

Facilities

Hotel Museo Spa Casa Santo Domingo offers amenities for your comfortable stay and unforgettable experiences
Delicious Dining!
“I was blown away by the variety of culinary delights available at the hotel. Each meal was a treat for the senses!” view full review
World-Class Spa!
“The spa services offered a serene escape. I indulged in a massage that left me feeling rejuvenated and relaxed.” view full review
Perfect Wedding Venue
“The wedding facilities were stunning! The decorations and ambiance made our family celebration truly magical.” view full review
Stunning Rooms!
“The room was beautifully decorated, with intricate architectural details that made our stay feel luxurious and unique.” view full review
Facilities: Perfect
9.3/10Review score

General

  • No smoking on site
  • Free Wi-Fi in public areas
  • Parking
  • Safe deposit box
  • 24-hour reception
  • Express check-in/ -out
  • Pets allowed
  • Rooms/ Facilities for disabled
  • Wheelchair access
  • 24-hour security
  • Luggage storage
  • Locker room
  • Allergy-free rooms
  • Currency exchange
  • ATM/Cash machine
  • Hairdresser
  • Smoke detectors
  • Fire extinguishers
  • Key access

Sports & Fitness

  • Fitness centre

Services

  • Paid airport shuttle
  • Room service
  • Housekeeping
  • Laundry
  • Dry cleaning
  • Tours/Ticket assistance
  • Welcome drink

Dining

  • In-room breakfast
  • Restaurant
  • Bar/ Lounge area
  • Special diet menus

Business

  • Business centre
  • Meeting/ Banquet facilities
  • Fax/Photocopying

Children

  • Cots
  • Children's buffet

Facilities for people with disabilities

  • Toilet for disabled

Spa & Leisure

  • Outdoor swimming pool
  • Beach umbrellas
  • Sun loungers
  • Sun terrace
  • Garden area
  • Spa & wellness centre
  • Solarium
  • Sauna
  • Steam room
  • Jacuzzi
  • Pedicure
  • Manicure
  • Waxing
  • Body scrub
  • Facial
  • Treatment room
  • Body wraps
  • Back massage
  • Head massage
  • Full body massage
  • Foot massage
  • Open-air bath
  • Make up services

Room features

  • Air conditioning
  • Mini-bar
  • Sitting area
  • Terrace
  • Garden furniture
  • Ironing facilities

Bathroom

  • Free toiletries

Media

  • Flat-screen TV
  • AM/FM alarm clock
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Hotel Museo Spa Casa Santo Domingo Location

3A, Calle Oriente N.28, Antigua, Guatemala, 03001
Map view
3A, Calle Oriente N.28, Antigua, Guatemala, 03001
City landmarks
Landmark
Arco de Santa Catalina
3100 ft
Landmark
Cerro de La Cruz
4100 ft
Park
Central Park
2400 ft
Square
The Plaza Central Park
2400 ft
Church
La Merced Church
3400 ft
Church
Catedral de San Jose
2300 ft
Church
Cathedral de Santiago
2300 ft
Ruin
Convento Santa Clara
2300 ft
Church
Iglesia de San Francisco El Grande
2400 ft
Landmark
La Recoleccion Architectural Complex
4600 ft
Church
Iglesia Escuela de Cristo
3100 ft
Gallery
el Fotografo
2100 ft
Gallery
Belfinart
2500 ft
Event hall
San Jose El Viejo
3200 ft
Landmark
Ayuntamiento
3400 ft
Nearby
3a Calle Oriente 28
Casa Santo Domingo Museums
1700 ft
4a Calle Oriente # 14 15C
ChocoMuseo
1600 ft
5a Calle Poniente
Palace of the Captain Generals
1100 ft
2a Avenida Norte y 2a Calle Oriente esquina. Antigua Guatemala
Convento de las Capuchinas
1600 ft
6a Calle Oriente
Tanque La Union
1000 ft
4 Calle Oriente # 10 Edificio El Jaulon
Casa del Jade
500 ft
Museum
Casa Popenoe
1400 ft
Avenida 1a
Paseo De Los Museos
100 ft
Museum
Casa Santo Domingo
1100 ft
Square
Antigua Guatemala
2000 ft
Church
Iglesia El Carmen
1400 ft
Museum
Antigua Guatemala Colonial Art Museum
1900 ft
Store
La bodegona
1300 ft
cnr 3a Calle Oriente & 3a Av Norte
Mercado de Artesanias El Carmen
1500 ft
3ra Avenida Norte # 20A
Healing Hands Therapy Spa
1500 ft
Restaurants
7 Caldos
100 ft
Calle Oriente 3a
Arrin Cuan Antigua
200 ft
Callejon Concepcion Casa #2
Samsara's Garden
700 ft
6 Street West # 33 Interior
Akai Sushi & Oriental
500 ft
4a Calle Oriente No. 39
Romeo y Julieta Guatemala
600 ft
4a Calle Oriente 39 100m from Morjan gas station
El Convento
1700 ft
2 Avenida Norte No. 11
Welten
1100 ft
4a Calle Oriente No. 21
Bistrot Cinq
1300 ft
4 a Calle Oriente # 7 Centro Histórico
La Casa del Ron
1300 ft
4 Calle Oriente # 22 Salida Hacia la Capital
Getting around
City Centre
Antigua14 min  ·  3700 ft
Airports
La Aurora (GUA)55 min  ·  22.7 mi
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Property information and rules
Check-in
from 15:00-23:59
Check-out
until 12 pm
Guest Parking
Private parking is possible on site for free.
Internet
Wireless internet is available in public areas for free.
Breakfast
The hotel offers a full breakfast at the price of US$22 per person per day. 
Children & extra beds
There are no extra beds provided in a room. 
Pets
Pets are allowed on request.
Number of rooms:
128

Reviews and Ratings

Feedback about Hotel Museo Spa Casa Santo Domingo from previous guests about their experience.
Review score
Based on 1058 verified reviews
8.9/10
Great
88%
Recommend
Breakfast
8.8/10
Cleanliness
9.4/10
Comfort
9.5/10
Facilities
9.3/10
Free Wi-Fi
8.2/10
Location
9.4/10
Paid Wi-Fi
8.0/10
Staff
9.2/10
Value for money
8.6/10
Guest reviews
based on 1457 reviews
9.1/10
No reviews yet on our siteUnfortunately, our guests have not yet left any reviews for this hotel, but you can read reviews from Booking.com.
Open reviews

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Check-in
21May2026Select date
Check-out
22May2026Select date
Rooms and Guests2 Guests, 1 Room
  • Overview
  • Rooms
  • Price calendar
  • Facilities
  • Location
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